Vincent Macaigne (born 19 October 1978) is a French actor, theatre director and film director. He is also a screenwriter and playwright.

Macaigne was raised in Paris, the son of a French businessman and an Iranian-born painter. He has an elder brother, who is a forensic doctor. He attended the CNSAD between 1999 and 2002, and staged his first play in 2004. Throughout the 2000s, he acted in several theatre productions and also wrote and staged a number of plays. He suffered two strokes at just thirty years old, one of which occurred after his 2009 staging of the theatrical adaptation of Fyodor Dostoyevsky's The Idiot. In an interview, he said the stroke has had no lasting consequences to his health.