Marcia Mae Jones was born on August 1, 1924, to an acting family. Her mother, Freda Jones, was an actress, and all three of her siblings - Margaret Jones, Macon Jones, and Marvin Jones - were child actors. But Marcia Mae had the most successful career, and she was the only one of her siblings to become a child star.

She made her acting debut when just six months old, when director James Cruze saw her in her baby carriage and immediately cast her as the baby in his film Mannequin (1926). Her first major role was in Night Nurse (1931), in which she played a sick child that a sinister hospital staff was trying to murder. By age 10, Marcia Mae had appeared in several dramatic films.