Brenda McDonald (born Brenda Olive Nicholls; February 12, 1931 – November 23, 2024) was a Canadian actress. Born in London, Brenda moved to Canada at 21, settling first in Toronto, then in Vancouver, where she met her first husband, Thomas Guy, and had four children with him.

She graduated from UBC with a teaching degree in 1977, soon after Thomas had died of a heart attack. She taught English, French and Drama for nine years before quitting to follow her dream of acting. Her career spanned 33 years. She performed on stage, in film, and in training and educational videos, as well as doing voice-over work. She was also very active in community theatre with North Vancouver Community Players and United Players in Jericho.