Hubert von Meyerinck was born in Potsdam on August 23, 1896, the son of a major. After his parents divorced, he was raised by his mother. From an early age he showed a strong interest in acting and began taking lessons as a child, despite his parents’ wish that he pursue a career as a priest. After completing school, he was drafted into military service during World War I but was discharged shortly afterward for health reasons.

In 1917, he made his stage debut at the Berliner Schauspielhaus as Lieutenant von Hagen in "Kolberg." Following an engagement at the Hamburger Kammerspiele from 1918 to 1920, he performed at numerous Berlin theatres and variety venues, including the revue "Es liegt was in der Luft" alongside Marlene Dietrich. He earned acclaim both for his cabaret performances at the famed Tingeltangel and for dramatic stage roles such as Mephisto in "Faust" and Mackie Messer in "Die Dreigroschenoper."