Dragan Nikolić was a Serbian actor. He studied at Dramatic Arts Academy in Belgrade. In 1967 he starred in the film Kad budem mrtav i beo, which was the beginning of a career that lasted 50 years. Dragan Nikolić has since appeared in many films of different genres and portrayed various characters, becoming one of the most recognizable actors in Serbian cinema. In 2000, he received the "Pavle Vuisić" Award for his lifework. From 2011 to 2013, he was the television host on the Serbian edition of quiz Who Wants to Be a Millionaire?.

His best known role was as Prle, a wisecracking World War II resistance fighter whom he portrayed in 1970s TV series Otpisani and Povratak otpisanih.