After graduating in Architecture, Stefania began a career in acting and worked with Pietro Germi, Bernardo Bertolucci, Peter Greenaway and Dario Argento. She moved to New York in the late 1970s, where she acted in Andy Warhol's 'Bad'. While in New York she decided to move behind the camera, and became a director.

With Francesca Marciano, she wrote and directed the film "Lontano da dove", presented at the Venice Film Festival (1983). In 1997 she wrote and directed another feature film "Un Paradiso di Bugie". Her career as director also includes the making of six feature films for the Italian television network MEDIASET.