Renée Lynn Fleming (born February 14, 1959) is an American soprano, known for performances in opera, concerts, recordings, theater, film, and at major public occasions. A recipient of the National Medal of Arts, Fleming has been nominated for 18 Grammy Awards and has won five times. In June 2023, the John F. Kennedy Center for the Performing Arts announced that Fleming would be one of the five artists recognized at the 2023 Kennedy Center Honors, which she received in December 2023. Other notable honors won by Fleming have included the Crystal Award from the World Economic Forum in Davos, the Chevalier de la Légion d'Honneur from the French government, Germany's Cross of the Order of Merit, Sweden's Polar Music Prize and honorary membership in England's Royal Academy of Music. Unusual among artists whose careers began in opera, Fleming has achieved name recognition beyond the classical music world. In May, 2023, Fleming was appointed by the World Health Organization as a Goodwill Ambassador for Arts and Health. On April 9, 2024, Penguin Random House published Fleming's anthology Music and Mind: Harnessing the Arts for Health and Wellness, a collection of essays about the health benefits of music and the arts, by scientists from leading research institutions, practitioners, educators, arts leaders, musicians, artists and writers.

Fleming has a full lyric soprano voice. She has performed coloratura, lyric, and lighter spinto soprano operatic roles in Italian, German, French, Czech, and Russian, aside from her native English. A significant portion of her career has been the performance of new music, including world premieres of operas, concert pieces, and songs composed for her by André Previn, Caroline Shaw, Kevin Puts, Anders Hillborg, Nico Muhly, Henri Dutilleux, Brad Mehldau, and Wayne Shorter. In 2008, Fleming became the first woman in the 125-year history of the Metropolitan Opera to solo headline a season opening night gala. Conductor Sir Georg Solti said of Fleming: "In my long life, I have met maybe two sopranos with this quality of singing; the other was Renata Tebaldi."