Amy Marie Madigan (born September 11, 1950) is an American actress. She has acted on stage and screen, and has received a Golden Globe Award, an Academy Award, as well as nominations for an Emmy Award. She has been married to actor Ed Harris since 1983.

Madigan made her film debut in the drama Love Child (1982), for which she was nominated for the Golden Globe Award for New Star of the Year – Actress. For playing a woman in a difficult marriage in the drama film Twice in a Lifetime (1985), she earned a nomination for the Academy Award and Golden Globe Award for Best Supporting Actress. She has also acted in Love Letters (1984), Alamo Bay (1985), Nowhere to Hide (1987), Uncle Buck (1989), Field of Dreams (1989), Female Perversions (1996), Pollock (2000), and Gone Baby Gone (2007). After a lack of "meaningful roles", she gained newfound attention for her performance in the horror film Weapons (2025).