Thuso Nokwanda Mbedu (born 8 July 1991) is a South African actress. She rose to prominence for her performance in the South African teen drama series Is'Thunzi for which she was nominated consecutively for an International Emmy in 2017 and 2018. Mbedu later appeared on the 2018 Forbes Africa 30 under 30 list.

In 2021, she starred in the Amazon Video limited series The Underground Railroad as Cora, which made her the first South African actress to lead an American television series, and earned her the Independent Spirit Award for Best Female Performance in a New Scripted Series. She then made her feature film debut in the American historical epic The Woman King (2022) in the role of Nawi.