Isaiah Washington IV (born August 3, 1963) is an American actor and internet personality. Following a series of film appearances, he came to prominence for portraying Dr. Preston Burke in the first three seasons of the series Grey's Anatomy from 2005 to 2007.

Washington began his career collaborating with director Spike Lee on the films Crooklyn (1994), Clockers (1995), Girl 6 (1996), and Get on the Bus (1996). He also appeared in the films Love Jones (1997), Bulworth (1998), True Crime (1999), Romeo Must Die (2000), Exit Wounds (2001), Ghost Ship (2002), and Hollywood Homicide (2003). In 2005, Washington landed his breakthrough role as Preston Burke on Grey's Anatomy. He was dismissed after the third season over allegations that he used homophobic slurs, although he would return for a guest appearance in 2014. From 2014 to 2018, Washington portrayed Thelonious Jaha on The CW's science fiction television series The 100.