Patti Harrison (born October 31, 1990) is an American actress and comedian. She is best known for her roles in comedy series such as Shrill (2019–2021) and I Think You Should Leave with Tim Robinson (2019–present), as well as the comedy film Together Together (2021), with the latter earning her a nomination for the Independent Spirit Award for Best Female Lead.

Harrison was born in Orient, Ohio, on October 31, 1990, the youngest of seven children of a Vietnamese mother and a White American father. Her father, a native of Detroit, was in the U.S. Army and met her mother during the Vietnam War when she was working as a janitor in his barracks. He died of a heart attack when Harrison was six years old. Her first involvement in comedy came from her participation in an improv team during her time at Ohio University, from which she did not graduate.