Ike Barinholtz (born February 18, 1977) is an American actor and comedian. He is best known for his starring roles in the comedy series MADtv (2002–2007), Eastbound & Down (2012), The Mindy Project (2012–2017), Bless the Harts (2019–2021), The Afterparty (2022), History of the World, Part II (2023), and The Studio (2025–present), the latter which earned him a Primetime Emmy nomination.

His films include Disaster Movie (2008), Neighbors (2014), Sisters (2015), Neighbors 2: Sorority Rising (2016), Suicide Squad (2016), Snatched (2017), Blockers (2018), Late Night (2019), The Hunt (2020), and The Unbearable Weight of Massive Talent (2022). He co-wrote the action comedy film Central Intelligence (2016) and directed, wrote, produced, and starred in the comedy film The Oath (2018).