An English actress and writer, mainly in comedy. She is known for her roles in the Garth Marenghi series and as the lead and co-writer of the 2012 film Sightseers. She wrote, directed and starred in the 2016 black comedy Prevenge, whilst pregnant herself.

Lowe was born in Coventry, West Midlands, England. She attended Kenilworth School and graduated from King's College, Cambridge, where she studied classics. At university she became involved in theatre and comedy.