Carla Gugino (/ɡʊˈdʒiːnoʊ/ guu-JEE-noh; born August 29, 1971) is an American actress. After early roles in the films Troop Beverly Hills (1989), This Boy's Life (1993), Son in Law (1993), and Snake Eyes (1998), Gugino received wider recognition for her starring roles in the Spy Kidstrilogy (2001–2003), Sin City (2005), Night at the Museum (2006), American Gangster (2007), Righteous Kill (2008), Race to Witch Mountain (2009), Sally Jupiter in Watchmen (2009), Sucker Punch (2011), Mr. Popper's Penguins (2011), San Andreas (2015), Gerald's Game (2017), Gunpowder Milkshake (2021), and Lisa Frankenstein (2024).

Gugino also starred in the crime drama series Karen Sisco (2003), the science fiction series Threshold (2005–2006), the crime drama series Jett (2019), and the supernatural horror miniseries The Haunting of Hill House (2018), The Haunting of Bly Manor (2020), and The Fall of the House of Usher (2023).