Manon Azem begins the theater as well as the dubbing at the age of 5 years. In 2001, she doubles the voice of actress Emma Watson who plays Hermione Granger in Harry Potter at the School of Wizards . She then becomes the official French voice in all films of the Harry Potter saga until 2015. She decides not to double it because, according to her, her voice has become too serious and incompatible with that of the British actress . She is also the French voice of Debby Ryan in Jessie and Joy Lauren in Desperate Housewives .

In 2006, she appears in the episode Bad slope of the series Diane, wife cop directed by Marc Angelo.