Tyler Christopher began his acting career on the daytime drama General Hospital as Nikolas Cassadine in July 1996. He immediately captured the hearts of fans and the notice of television critics. He won the Soap Opera Digest Award as "Best Newcomer" in 1997. His first run on the show was from 1996 to 1999. Christopher returned to the show in 2003. He was nominated for a Daytime Emmy Award for Best Younger Actor in 1998 and Best Supporting Actor in 2005 and 2006.

During his hiatus from General Hospital, Christopher was cast as a regular (Ethan) on The Pretender and the two subsequent Pretender TV Movies. He landed the lead role in the CBS Pilot "Sam's Circus" and also the UPN Pilot "One for the Money". In 2006 he was cast in the ABC pilot "Secrets of a Small Town". Tyler made numerous guestappearances on Charmed and Angel, CSI: Las Vegas, Boomtown, JAG, and many more.