Ultramarathoner, author, and public speaker. Throughout his running career, Jurek was one of the most dominant ultramarathon runners in the world, winning the Hardrock Hundred (2007), the Badwater Ultramarathon (2005, 2006), the Spartathlon (2006, 2007, 2008), and the Western States 100 Mile Endurance Run (1999–2005). In 2010, at the 24-Hour World Championships in Brive-la-Gaillarde, France, Jurek won a silver medal behind Shingo Inoue and set a new US record for distance run in 24 hours with 165.7 miles (an average pace of 8 minutes and 42 seconds per mile). In 2015, Jurek set the Fastest Known Time running record for the 2,189-mile Appalachian Trail.

Jurek has followed a vegetarian diet since 1997, and a vegan diet since 1999.