Jamie Clayton (born January 15, 1978) is an American actress and model. Clayton is best known for starring as Nomi Marks in the Netflix original series Sense8, Sasha Booker in the third season of Designated Survivor and Tess Van De Berg in Showtime's The L Word: Generation Q. She portrays Pinhead in the 2022 Hellraiser film.

Clayton was raised in San Diego, California. Her father, Howard Clayton, was a criminal defense attorney, and her mother, Shelley, is an event planner. When she was 19, Clayton moved to New York City to pursue a career as a makeup artist.