Rene Marie Russo (born February 17, 1954) is an American actress and former model. She began her career as a fashion model in the 1970s, appearing on magazine covers such as Vogue and Cosmopolitan.

She made her film debut in the 1989 comedy Major League, and rose to international prominence in a number of thrillers and action films throughout the 1990s, including Lethal Weapon 3 (1992), In the Line of Fire (1993), Outbreak (1995), Get Shorty (1995), Ransom (1996), Lethal Weapon 4 (1998), and The Thomas Crown Affair (1999).