Lima was a series regular in the internet comedy Poor Paul (2008-2009) and later became a series regular in Fox's medical drama The Mob Doctor (2012-2013). She had a recurring role in NBC's spy series Allegiance (2015), was a series regular in ABC's thriller The Family (2016) and has a recurring role in Fox's action drama Lethal Weapon (2016). From 2016-2017, Lima played lesbian Detective Maggie Sawyer in season two & three of The CW's Supergirl.

In 2018, Lima played the character of psychiatrist Krista Dumont in the second season of Netflix's The Punisher.