Despina Tomazani (Greek: Δέσποινα Τομαζάνη, 1945–2026) was a Greek actress, author, poet, and screenwriter with a distinctive and multifaceted career in the arts.

She was born on Chios on June 1, 1945, with roots in Ayvalik (Asia Minor) and Kotyora (Pontus). She studied theater in Athens and subsequently film and theater at Stockholm University.