Melanie Straub (born 1976 in Waiblingen) is a German actress.

Melanie Straub wanted to become an actress even as a child; however, she initially began with pantomime, as she felt she was too shy at the time. After graduating from high school, and at her parents' request, she first completed training as a physiotherapist; she subsequently worked for about a year in a psychiatric facility, where she led a theater group for patients with substance use disorders.