Regena Cassandrra (born 13 December 1990) is an Indian actress and model who works predominantly in Telugu and Tamil cinema, as well as Hindi and Kannada productions. She began her acting career as a child anchor on the children's television channel Splash and made her acting debut in the Tamil romantic comedy *Kanda Naal Mudhal* (2005). She later appeared in short films and made her Kannada debut in K. M. Chaitanya's *Suryakaanti* (2010). Her Telugu breakthrough came with Tatineni Satya's *Siva Manasulo Sruthi* (*SMS*, 2012), for which she won the SIIMA Award for Best Female Debut – Telugu.

Her subsequent films include *Routine Love Story* (2012), Pandiraj's Tamil comedy *Kedi Billa Killadi Ranga* (2013), Maruthi's *Kotha Janta* (2014), *Ra Ra... Krishnayya* (2014), K. S. Ravindra's action film *Power* (2014), A. S. Ravi Kumar Chowdary's *Pilla Nuvvu Leni Jeevitham* (2014), Harish Shankar's *Subramanyam for Sale* (2015), *Rajathandhiram* (2015), the romantic comedy *Jyo Achyutananda* (2016), and Lokesh Kanagaraj's hyperlink thriller *Maanagaram* (2017). She also appeared in Prasanth Varma's psychological ensemble film *Awe!* (2018), Venkat Ramji's mystery thriller *Evaru* (2019), and Selvaraghavan's horror drama *Nenjam Marappathillai* (2021).