She began her career in television hosting shows such as Maa Talkies and Heart Beat before transitioning to feature films with supporting roles in Dongodu (2003) and Bhageeratha (2005). She subsequently established herself as a character actress with appearances in Telugu films including Bommarillu (2006), Dubai Seenu (2007), Ready (2008), Ullasanga Utsahanga (2008), Neninthe (2008), Ye Maaya Chesave (2010), Prasthanam (2010), Brindavanam (2010), Dookudu (2011), Life Is Beautiful (2012), Naayak (2013), Baadshah (2013), Srimanthudu (2015), Soggade Chinni Nayana (2016), and Sarrainodu (2016).

In Tamil cinema, Vani has appeared in films such as Uthama Puthiran (2010), Kadhalil Sodhappuvadhu Yeppadi (2012), Jilla (2014), Mersal (2017), Viswasam (2019), and Annabelle Sethupathi (2021). Her later Telugu screen credits include Rarandoi Veduka Chudham (2017), Republic (2021), Naandhi (2021), Bangarraju (2022), Swathi Muthyam (2022), the anthology series Meet Cute (2022), and Parijatha Parvam (2024).