Meaghan Oppenheimer grew up in Tulsa, Oklahoma, and was a former child actor, working in various regional theatre productions and television shows. She graduated from Holland Hall, and then New York University—Tisch School of the Arts in 2009. Afterward, she relocated to Los Angeles to begin a screenwriting career.

In 2010, Oppenheimer wrote and starred in Hot Mess, a film about two roommates that become friends-with-benefits. She has written screenplays for a number of projects, including Fear the Walking Dead. She co-wrote the screenplay for 2015's We Are Your Friends with film maker Max Joseph.