Orchidea De Santis, pseudonym of Orchidea De Sanctis (Bari, December 20, 1948), is an Italian actress.

Of Salento origins but born in Bari due to her father's work as an officer in the Navy, she moved with her family, who ran a hotel in the capital of Puglia, first to Gallipoli and then to Rome, following her sister who was sixteen years older. At the beginning she was also a singer and, later, a theater actress. She has ranged from cinema to radio, from theater to music, until arriving on television. From 2006 to 2013 she managed a blog. She collaborates with various animal rights and environmental associations.